Antibody Drug Research Based on SPR Technology

The background of antibody drug research

Antibodies are a type of immunoglobulin that can specifically bind to antigens. The unique biological activity of antibodies makes them play an important role in disease diagnosis, immune control and basic research. Initially, people used specific antigens to immunize animals to prepare corresponding antisera for the treatment of corresponding diseases. Subsequently, researchers invented monoclonal antibody and polyclonal antibody technologies, which made it possible to produce high-specificity and homogeneous antibodies on a large scale. In recent years, with the development of molecular biology, people have been able to prepare human-mouse chimeric antibodies, humanized antibodies, and human antibodies through antibody engineering technology. In addition to antibody drugs, the development of various antibody detection kits also occupies an important position in the detection and diagnosis of diseases. Antibody detection is faster and more intuitive than other detection methods. It can quickly and qualitatively detect whether there is a certain antibody in human plasma, which can be used to judge whether a certain disease is affected. Antibodies are proteins in nature, so in the development of antibody research, the detection of interactions between proteins and other biomolecules is very important.

Surface plasmon resonance (SPR) in the process of antibody drug research

Antibody research occupies an important proportion in biopharmaceuticals, mainly including the following two aspects. First of all, the most important aspect is the research and development of various recombinant antibody drugs. In addition, as a rapid way of diagnosing diseases, the demand for research and development of antibody detection reagents and kits is also increasing. Because antibodies are proteinaceous substances, the development of antibody drugs and antibody detection reagents is inseparable from the affinity, specificity and kinetic detection between proteins and other biologically active molecules. As shown in the figure below, the SPR technology platform can realize intermolecular interaction detection with high throughput and high selectivity.

Fig.2 BIAchip^TM in the process of antibody drug research 

First of all, in addition to providing you with conventional standard antibody-antigen detection chips, our SPR technology platform also provides you with customized services for special detection chips. You can communicate with us about your experimental project to inform your needs, and we will provide you with customized solutions within 1-3 days. In addition, SPR technology can provide high-efficiency assistance for the research and development of your antibody drugs and detection kits, reducing unnecessary time and money waste. The high throughput of SPR technology allows you to repeat the antibody drug development process, which can greatly improve the efficiency of the antibody drug development process. If you choose the high-throughput SPR technology platform, your antibody drug development work will surely be greatly promoted.

Choosing SPR technology platform of Creative Proteomics, you will greatly save time and money costs owing to high-throughput intermolecular interaction detection. All services are available on a 24/7/365 basis. If you have any questions or suggestions about SPR, please feel free to contact us right now.

For research use only. Not intended for any clinical use.